Cov khoom

Kev tsim cov p-hydroxyacetophenone siv phenol ua raw khoom, thiab tau txais los ntawm acylation thiab transposition.Sib tov phenol thiab acetyl chloride, maj mam ua kom sov kom txog thaum tsis muaj hydrogen chloride tawm los npaj phenyl acetate, ntxiv rau nitrobenzene, ntxiv aluminium trichloride tom qab txias, do rau 2-3 teev, ces ncuav rau hauv dej txias, ntxiv 1: 3 hydrochloric acid kom txog thaum lub caij ntuj no. Nws yog txias, rho tawm nrog ether, distill lub ether los ntawm cov extract, distill nitrobenzene thiab cov by-product o-hydroxyacetophenone los ntawm chav distillation, thiab tawm cov p-hydroxyacetophenone nyob rau hauv residue.Cov khoom yog tau los ntawm extraction thiab recrystallization.

[Industry Chain] Upstream khoom phenol, acetyl chloride, thiab p-hydroxyacetophenone.Cov khoom nram qab no: 4-quinoxalinyl-2-phenol, N-acetaminophen, 4-hydroxystyrene, atenolol, 3'-chloromethyl-4'-hydroxyacetophenone, 4-benzyl Oxy-3-nitroacetophenone, p-hydroxyphenethyl cawv, 1-{4- (acetoxy)-3-[(acetoxy)methyl]phenyl}-2-bromoethanone, 2- (Benzyl-tert-butylamino)-4'-hydroxy-3'-hydroxymethylacetophenone diacetate hydrochloride, 4-acetoxystyrene.