Cov khoom

PO cov khoom lag luam muaj cov tshuaj tiv thaiv dandruff thiab tiv thaiv khaus khaus, tshwj xeeb los tiv thaiv dandruff mechanism, solubility zoo heev thiab recombination, kev nyab xeeb, tsis muaj tshuaj lom, tsis ua rau khaus, thiab feem ntau yog siv hauv cov tshuaj zawv plaub hau thiab cov khoom tu plaub hau.PO muaj cov nyhuv antipruritic zoo heev, thiab tseem muaj kev ua kom tsis muaj menyuam thiab deodorization, yog li nws tau siv hauv cov tshuaj pleev ib ce kom ua tiav cov txiaj ntsig zoo.PO muaj qhov dav-spectrum tua cov nyhuv ntawm fungi thiab pwm, thiab muaj kev kho mob zoo ntawm ko taw thiab tes ringworm.Nws tuaj yeem siv los ua cov tshuaj tua kab mob hauv cov tshuaj pleev ib ce, ua cov tshuaj tua kab mob hauv xab npum, thiab ua tus neeg sawv cev thickening.Yog li ntawd, PO yog ib tug multifunctional anti-dandruff thiab antipruritic bactericide, uas yog dav siv nyob rau hauv cov tshuaj zawv plaub hau thiab cov plaub hau tu cov khoom, da dej pleev, tshuaj pleev ib ce, thiab detergents.

Piroctone olamine, ethanolamine ntsev ntawm hydroxamic acid derivative Piroctone, yog hydroxypyridone anti-mycotic tus neeg saib xyuas.Piroctone olamine nkag mus rau hauv lub cell membrane thiab tsim complexes nrog hlau ions, inhibiting zog metabolism hauv mitochondria [1].Piroctone olamine (PO) yog ethanolamine ntsev ntawm hydroxamic acid derivative Piroctone.Tag nrho cov kab mob Candida qhia qhov tsawg kawg nkaus inhibitory concentrations (MICs) rau Piroctone olamine (0.125-0.5 μg / mL) thiab Amphotericin B (AMB) (0.03-1 μg / mL).

Qhov kev ua haujlwm no yog tsom rau kev soj ntsuam cov tshuaj tiv thaiv kab mob ntawm Piroctone olamine hauv kev kho mob hauv plab candidiasis hauv cov qauv sim siv Swiss nas.Kev kho mob nrog Piroctone olamine (0.5 mg / kg) yog ua 72 teev tom qab kis kab mob los ntawm kev tswj hwm intraperitoneal.Rau kev sib piv, ib pawg tsiaj (n=6) raug kho nrog Amphotericin B (0.5 mg / kg).Kev kuaj mob mycological yog tsim los ntawm kev sau lub siab, spleen thiab ob lub raum.Cov ntaub ntawv hais txog kev loj hlob ntawm cov kab mob fungal thiab kev tuag raug txheeb xyuas los ntawm Cov Tub Ntxhais Kawm t test thiab tsom xam ntawm qhov sib txawv, nrog rau theem ntawm qhov tseem ceeb ntawm P<0.05.Qhov sib txawv ntawm cov kab mob fungal loj hlob ntawm pawg tswj hwm thiab pab pawg kho mob (Piroctone olamine thiab Amphotericin B) yog qhov tseem ceeb (P<0.05)